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US 2022/0089682 A1Published application
Methods of treating liver disease
OwnerPedro SANTAMARIAinventor
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Abstract
Described herein are compositions and methods useful for treating hepatic inflammatory disorders. The compositions and methods utilize ubiquitous, non-tissue specific antigens associated with major histocompatibility complexes (MHCs) and coupled to a nanoparticle core to induce regulatory T cells and regulatory B cells.
Claims73
A composition for use in treating a hepatic inflammatory disease, the composition comprising:
- a plurality of antigen-major histocompatibility complexes (antigen-MHCs), coupled to a nanoparticle core possessing a diameter of between 1 and about 100 nanometers, wherein the plurality of antigen-MHCs comprise a ubiquitous autoantigen associated with a binding groove of the MHC, wherein the ubiquitous autoantigen is not a liver specific antigen.
A method of treating a hepatic inflammatory disease in an individual comprising administering to an individual a composition comprising:
- a plurality of antigen-major histocompatibility complexes (antigen-MHCs), coupled to a nanoparticle core possessing a diameter of between 1 and about 100 nanometers, wherein the plurality of antigen-MHCs comprise a ubiquitous autoantigen associated with a binding groove of the MHC, wherein the ubiquitous autoantigen is not a liver specific antigen.
Dependencies are inferred from the claim text.