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US 2022/0089674 A1Published application
Engineered immune cells that modulate receptor expression
AssigneeA2 Biotherapeutics, Inc.
InventorAlexander Kamb
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Abstract
The present disclosure provides engineered immune cells and methods for their creation and use. The immune cells comprise activating and blocking receptors, and binding of the blocking receptors to cognate ligands causes reduced surface expression of the activating receptors.
Claims20
An engineered immune cell comprising:
- an activating receptor expressed on a surface of the engineered immune cell, wherein binding of the activating receptor to a first ligand on a target cell promotes a cytotoxic response by the engineered immune cell;
- and
- a blocking receptor expressed on the surface of the engineered immune cell, wherein binding of the blocking receptor to a second ligand on the target cell causes the engineered immune cell to exhibit reduced surface expression of the activating receptor.
A method for treating a cancer, the method comprising:
- providing an engineered immune cell to a patient, wherein the engineered immune cell comprises an activating receptor and a blocking receptor, each expressed on a surface of the engineered immune cell, wherein:
- when the engineered immune cell encounters a tumor cell of the patient, the activating receptor binds to a first ligand on the tumor cell while the blocking receptor remains unbound, thereby promoting a cytotoxic response by the engineered immune cell that results in a cytotoxic effect on the tumor cell;
- and
- when the engineered immune cell encounters a normal cell of the patient the blocking receptor binds to a second ligand on the normal cell and causes the engineered immune cell to exhibit reduced surface expression of the activating receptor, thereby causing a signal from the blocking receptor to dominate a signal from the activating receptor and prevent the cytotoxic response by the engineered immune cell.
1 more element
Dependencies are inferred from the claim text.