PROTEINS AND FLUOROPHORE-CONTAINING COMPOUNDS SELECTIVE FOR NaV1.7
OwnerPaula Demetrio DE SOUZA FRANCA, Junior GONZALES +3inventors
InventorsPaula Demetrio DE SOUZA FRANCA, Junior GONZALES, Jason LEWIS, Thomas REINER, Glenn F. KING
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Abstract
The present technology is directed to fluorophore-containing compounds useful in the imaging of peripheral neurons as well as to proteins useful in the treatment (including management) of pain.
Claims29
A compound of a fluorophore conjugated to a side chain of an amino acid of a peptide of SEQ ID NO:
- 1, or a conservative amino acid substitution variant thereof, a pharmaceutically acceptable salt thereof, and/or a solvate thereof.
(canceled)
-11. (canceled)
-14. (canceled)
A protein of SEQ ID NO:
- 1, or a conservative amino acid substitution variant thereof, a pharmaceutically acceptable salt thereof, and/or a solvate thereof.
(canceled)
(canceled)
(canceled)
A compound of a fluorophore conjugated to a side chain of an amino acid of a peptide of SEQ ID NO:
- 2 or a conservative amino acid substitution variant thereof, a pharmaceutically acceptable salt thereof, and/or a solvate thereof.
-26. (canceled)
The compound of claim 25, wherein α3 is
-33. (canceled)
-36. (canceled)
Dependencies are inferred from the claim text.