Microbially derived peptides and proteins for immunotherapy
AssigneeSecond Genome, Inc.
InventorsYuliya Katlinskaya, Helena Kiefel, Kareem L. Graham, Todd Z. DeSantis, Sunit Jain, Andrew W. Han, Karim Dabbagh
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Abstract
The disclosure provides therapeutic peptides and pharmaceutical compositions comprising the peptides, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic peptides are useful as immunotherapeutics for modulating regulatory and effector molecules of the mammalian immune system to mitigate disease.
Claims68
An immunotherapeutic pharmaceutical composition for modulating regulatory and effector molecules of the mammalian immune system to treat a disease, comprising:
- a) a purified therapeutic peptide comprising an amino acid sequence having at least 70% sequence identity to SEQ ID NO:1;
- and
- b) a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising:
- a) a therapeutic peptide comprising an amino acid sequence having at least 70% sequence identity to SEQ ID NO:1;
- and
- b) a pharmaceutically acceptable carrier.
A method for treating a disease in a subject in need thereof, comprising:
- a) administering to the subject an immunotherapeutic pharmaceutical composition, comprising:
- i. a purified therapeutic peptide comprising an amino acid sequence having at least 70% sequence identity to SEQ ID NO:1;
- and
- ii. a pharmaceutically acceptable carrier.
A method for treating a disease in a subject in need thereof, comprising:
- a) administering to the subject a pharmaceutical composition, comprising:
- i. a therapeutic peptide comprising an amino acid sequence having at least 70% sequence identity to SEQ ID NO:1;
- and
- ii. a pharmaceutically acceptable carrier.
An isolated peptide comprising an amino acid sequence of SEQ ID NO:1.
A composition comprising an isolated peptide comprising an amino acid sequence of SEQ ID NO:1.
A host cell comprising an exogenous polynucleotide, the polynucleotide encoding a protein comprising an amino acid sequence having at least about 85% sequence identity to SEQ ID NO:
- 1.
The host cell of any one of claims 44-56, wherein the host cell is a prokaryotic cell.
An expression vector, comprising:
- a polynucleotide, which encodes a protein comprising an amino acid sequence having at least about 85% sequence identity to SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.