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US 2022/0089650 A1Published application
Methods and compositions for delivery of agents across the blood-brain barrier
AssigneeThe Brigham and Women S Hospital, Inc.
InventorFengfeng Bei
Life of this patent
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Abstract
Sequences that enhance permeation of agents into cells and/or across the blood brain barrier, compositions comprising the sequences, and methods of use thereof.
Claims21
(canceled)
An adeno-associated virus (AAV) vector comprising an AAV capsid, wherein the AAV capsid comprises a peptide insert of up to 21 amino acids, and wherein the peptide insert comprises 5-7 amino acids of TVSALFK (SEQ ID NO:
- 8).
Dependencies are inferred from the claim text.