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US 2022/0089638 A1Published application
Dithiocarbamate stapled peptides and methods of making and use thereof
AssigneeUniversity of Maryland, Baltimore
InventorsWuyuan LU, Xiang LI
Life of this patent
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Abstract
Dithiocarbamate stapled peptides and methods of making and using the same for treating a condition associated with p53, such as cancer, are provided.
Claims28
A method for preparing a dithiocarbamate stapled peptide comprising:
- contacting a peptide comprising a dehydroalanine residue and a lysine residue with carbon disulfide to form a dithiocarbamate linker.
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A stapled peptide comprising a peptide backbone and a staple, wherein:
- the peptide backbone comprises three or more amino acid residues;
- the staple comprises a dithiocarbamate moiety and is attached to a cysteine residue and a lysine residue;
- and
- the cysteine and lysine residues are separated by one or more amino acid residues.
1 more element
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Dependencies are inferred from the claim text.