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US 2022/0089637 A1Published application
Steroid compound, and use thereof and preparation method therefor
AssigneeChengdu Kanghong Pharmaceutical Co., Ltd.
InventorsXiao KE, Yiqian WANG, Pei CHEN
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Abstract
The present invention relates to a steroid compound, a use thereof and a preparation method therefor. It is expected that such compound can effectively treat mental and neurological diseases, and has good active efficacy, pharmacokinetic (PK) performance, oral bioavailability, stability, safety, clearance rate, and/or metabolic performance and the like.
Claims19
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C1-6 alkoxy, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, or substituted or unsubstituted C3-6 carbocyclyl,
- R2 is hydrogen, halogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C1-6 alkoxy, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl,
- R3 is hydrogen, unsubstituted C1-6 alkyl or —CH2ORa, wherein Ra is hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C1-6 alkoxy, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 carbocyclyl;
- L is —C(Rb)(Rb)—, each Rb is independently hydrogen or C1-C6 alkyl, n is an integer of 0 to 3;
- R4 is halogen or substituted or unsubstituted heteroaryl or heterocyclyl.
4 more elements
Dependencies are inferred from the claim text.