Crystalline forms of dexamethasone dimers and uses thereof
AssigneeRipple Therapeutics Corporation
InventorsIan Charles PARRAG, Matthew Alexander John STATHAM, Emma-Louise Elizabeth MOORE, Bahareh KHALILI, Judith Anne WILLIAMS, Elizabeth POLOZ, Boris GORIN
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Abstract
The disclosure features polymorphs of a prodrug dimer of dexamethasone linked at the 21-C and 21′-C carbons via a carbonate-triethylene glycol-carbonate linker. Also disclosed are pharmaceutical compositions and articles comprising said polymorphs, and the use thereof in the treatment of a disease or condition, e.g. via the extended or controlled release of dexamethasone from said articles.
Claims35
A solid crystalline form of Compound 1 characterized by a powder X-ray diffraction (PXRD) diffractogram obtained using Cu(λ=1.54 Å) radiation comprising peaks expressed in degrees 2θ (±0.2°) at:
- 3.8°, 7.6°, and 12.1°.
A solid crystalline form of Compound 1 characterized by a powder X-ray diffraction (PXRD) diffractogram obtained using Cu(λ=1.54 Å) radiation comprising peaks expressed in degrees 2θ (±0.2°) at:
- 3.9°, 7.9°, 11.9°, and 15.8°.
A solid crystalline form of Compound 1 characterized by a powder X-ray diffraction (PXRD) diffractogram obtained using Cu(λ=1.54 Å) radiation comprising peaks expressed in degrees 2θ (±0.2°) at:
- 8.0°, 9.8°, 12.1°, and 13.8°.
A solid crystalline form of Compound 1 characterized by a powder X-ray diffraction (PXRD) diffractogram obtained using Cu(λ=1.54 Å) radiation comprising peaks expressed in degrees 2θ (±0.2°) at:
- 8.9°, 11.4°, 14.1°, and 16.4°.
A solid crystalline form of Compound 1 characterized by a powder X-ray diffraction (PXRD) diffractogram obtained using Cu(λ=1.54 Å) radiation comprising peaks expressed in degrees 2θ (±0.2°) at:
- 5.6°, 6.5°, 8.1°, 12.7°, and 15.2°.
A solid crystalline form of Compound 1 characterized by a powder X-ray diffraction (PXRD) diffractogram obtained using Cu(λ=1.54 Å) radiation comprising peaks expressed in degrees 2θ (±0.2°) at:
- 3.7°, 7.4°, and 16.7°.
A solid crystalline form of Compound 1 characterized by a powder X-ray diffraction (PXRD) diffractogram obtained using Cu(λ=1.54 Å) radiation comprising peaks expressed in degrees 2θ (±0.2°) at:
- 3.5°, 7.6°, 9.6°, and 10.7°.
A solid crystalline form of Compound 1 characterized by a powder X-ray diffraction (PXRD) diffractogram obtained using Cu(λ=1.54 Å) radiation comprising peaks expressed in degrees 2θ (±0.2°) at:
- 7.2°, 9.3°, 11.9°, 14.6°, and 17.0°.
Dependencies are inferred from the claim text.