Compounds and methods for the treatment of pathogenic neisseria

A borate compound of formula (I):

• (Cat+-LK)m—B−—(R1)n(Cat+)p(A−)q (I)
• wherein:
• m and n are integers from 0 to 4, with the proviso that m+n=4,
• p is an integer and is the larger of 0 and 1−m,
• q is an integer and is the larger of 0 and m−1,
• each R1 independently represents:
• alkyl, alkenyl, alkynyl, alkenynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkenynyl, heterocycloalkyl, heterocycloalkenyl, heterocycloalkynyl, heterocycloalkenynyl, aryl, or heteroaryl, all of which being unsubstituted or substituted with one or more of the following:
• —R2, —OR2, —P(R2)2, —SR2, —O—CO—R2, —CO—O—R2, —CO—R2, —CO—N(R2)2, —N(R2)2, —NR2—CO—R2, —C═NR2, —C≡N, —NO2, —N3, halogen, or -LK-R3, or
• —H, —OR2, —P(R2)2, —SR2, —O—CO—R2, —CO—O—R2, —CO—R2, —CO—N(R2)2, —N(R2)2, —NR2—CO—R2, —C═NR2, —C≡N, —NO2, —N3, halogen, or -LK-R3,
• and/or
• two R1 together with the boron atom to which they are attached form a cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkenynyl, heterocycloalkyl, heterocycloalkenyl, heterocycloalkynyl, heterocycloalkenynyl, aryl, or heteroaryl, all of which being unsubstituted or substituted with one or more of the following:
• —R2, —OR2, —P(R2)2, —SR2, —O—CO—R2, —CO—O—R2, —CO—R2, —CO—N(R2)2, —N(R2)2, —NR2—CO—R2, —C═NR2, —C≡N, —NO2, —N3, halogen, or -LK-R3,
• each R2 independently represents:
• alkyl, alkenyl, alkynyl, alkenynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkenynyl, heterocycloalkyl, heterocycloalkenyl, heterocycloalkynyl, heterocycloalkenynyl, aryl, or heteroaryl, all of which being unsubstituted or substituted with one or more of the following:
• —R4, —OR4, —P(R4)2, —SR4, —O—CO—R4, —CO—O—R4, —CO—R4, —CO—N(R4)2, —N(R4)2, —NR4—CO—R4, —C═NR4, —C≡N, —NO2, —N3, halogen, or -LK-R3, or
• —H, —OH, —P(R4)2, —SH, —O—CO—H, —COOH, —CO—H, —CO—NH2, —NH2, —NH—CO—H, —C═NH, —C≡N, —NO2, —N3, halogen, or -LK-R3,
• each R3 independently represents is a pharmaceutically acceptable compound;
• each R4 independently represents:
• H, alkyl, alkenyl, alkynyl, alkenynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkenynyl, heterocycloalkyl, heterocycloalkenyl, heterocycloalkynyl, heterocycloalkenynyl, aryl, heteroaryl, —OH, —SH, —O—CO—H, —COOH, —CO—H, —CO—NH2, —NH2, —NH—CO—H, —C═NH, —C≡N, —NO2, —N3, halogen, or -LK-R3,
• each -LK- independently represents a covalent bond or a linking group,
• each Cat+ independently represents a pharmaceutically acceptable cation, and
• each A− independently represents a pharmaceutically acceptable anion,
• with the proviso that no more than two R1 are halogen.