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US 2022/0089619 A1Published application
Synthesis strategy for gap protecting group
AssigneeGAP Peptides LLC
InventorCole Seifert
Life of this patent
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Abstract
The present invention relates to a novel synthesis method to form particular molecules. These molecules have multiple uses, most notably in the field of protecting groups used throughout organic and synthetic chemistry. The disclosed method is safer, more cost- and time-effective, and more amenable to large scale production than those currently known in the art. The protecting groups synthesized are useful in GAP peptide synthesis.
Claims14
A protecting group for chemical synthesis, selected from a group consisting of:
- wherein:
- Y is selected from the group consisting of:
- —O—, —S—, and —NH—;
- Z is selected from the group consisting of:
- —O—, —S—, —NMe, and —NH—;
- R′ is selected from the group consisting of:
- —H, -Me, iPr, tBu, Ph, 2-ClPh, 4-ClPh, 3-ClPh, 3,5-Cl2Ph, —(CH2)n-CH3 where n=any integer >0 or <20;
- and
- R″ is selected from the group consisting of:
- H, Me, iPr, tBu, Ph, 2-ClPh, 4-ClPh, 3-ClPh, 3,5-Cl2Ph, —(CH2)n-CH3 where n=any integer >0 or <20.
7 more elements
A method of synthesizing a protecting group, wherein the protecting group is selected from a group consisting of:
- wherein:
- R is selected from the group consisting of:
- —H, -Me, and —OMe;
- Y is selected from the group consisting of:
- —O—, —S—, and —NH—;
- Z is selected from the group consisting of:
- —O—, —S—, —NMe, and —NH—;
- R′ is selected from the group consisting of:
- H, Me, iPr, tBu, Ph, 2-ClPh, 4-ClPh, 3-ClPh, 3,5-Cl2Ph, —(CH2)n-CH3 where n=any integer >0 or <20;
- and
- R″ is selected from the group consisting of:
- H, Me, iPr, tBu, Ph, 2-ClPh, 4-ClPh, 3-ClPh, 3,5-Cl2Ph, —(CH2)n-CH3 where n=any integer >0 or <20.
9 more elements
Dependencies are inferred from the claim text.