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US 2022/0089595 A1Published application
Heterocyclic compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsTakaharu Hirayama, Yoshiteru Ito, Noriyuki Nii, Youichi Kawakita, Shinichi Imamura
Life of this patent
Estimating the term…
Abstract
Provided is a compound that can have an effect of inhibiting MALT1 and is expected as useful as a prophylactic or therapeutic drug for cancer, etc. A compound represented by formula (I) [wherein each symbol is as defined in the description], a salt thereof, or a cocrystal, a hydrate or a solvate of the same.
Claims10
A compound represented by a formula (I):
- (wherein
- A represents
- R1 represents 1) a hydrogen atom, 2) a halogen atom, 3) a cyano group, 4) a C1-3 alkyl group which may be substituted with 1 to 3 halogen atoms, 5) a C1-3 alkoxy group, 6) a C3-6 cycloalkyl group, or 7) a phenyl group;
- R2 represents 1) a hydrogen atom or 2) a halogen atom;
- R3 represents 1) a C1-6 alkyl group which may be substituted with 1 to 3 substituents selected from a C1-3 alkoxy group, a hydroxyl group and a halogen atom, 2) a pyrazolyl group which may be substituted with 1 to 3 substituents selected from a C1-3 alkyl group and a halogen atom, 3) a C3-6 cycloalkyl group, 4) an amino group di-substituted with a C1-3 alkyl group, or 5) a phenyl group which may be substituted with 1 to 3 halogen atoms;
- R4 and R6 represent 1) a hydrogen atom, 2) a halogen atom, 3) a C1-3 alkyl group which may be substituted with 1 to 3 substituents selected from a) a hydroxyl group, b) a C1-3 alkoxy group which may be substituted with a 4-methoxyphenyl group and c) a halogen atom, or 4) a C1-3 alkoxy group which may be substituted with 1 to 3 halogen atoms;
- R5, R7 and R9 represent 1) a C1-6 alkyl group which may be substituted with 1 to 3 C1-3 alkoxy groups or 2) a phenyl group which may be substituted with 1 to 3 halogen atoms;
- R8 represents a C1-3 alkyl group;
- and
- B represents
- 1) a phenyl group which may be substituted with 1 to 3 substituents selected from a) a halogen atom, b) a cyano group, c) a C1-3 alkoxy group which may be substituted with 1 to 3 halogen atoms, and d) a triazolyl group,
- 2) a C3-6 cycloalkyl group which may be substituted with 1 to 3 substituents selected from a) a C1-3 alkyl group which may be substituted with 1 to 3 halogen atoms and b) a halogen atom,
- 3) a pyridyl group which may be substituted with 1 to 3 substituents selected from a) a halogen atom, b) a cyano group, c) a C1-3 alkyl group which may be substituted with 1 to 3 halogen atoms, d) a C1-3 alkoxy group which may be substituted with 1 to 3 substituents selected from a halogen atom and a C1-3 alkoxy group, e) a pyrazolyl group which may be substituted with 1 to 3 C1-3 alkyl groups, f) an imidazolyl group which may be substituted with 1 to 3 C1-3 alkyl groups, g) a triazolyl group which may be substituted with 1 to 3 C1-3 alkyl groups which may be substituted with 1 to 3 substituents selected from a C1-3 alkoxy group and a halogen atom, h) an azetidinyl group, i) a pyrrolidonyl group, j) a tetrazolyl group which may be substituted with 1 to 3 C1-3 alkyl groups, k) a pyrimidinyl group, and 1) an oxazolyl group,
- 4) a pyrazolyl group which may be substituted with 1 to 3 substituents selected from a) a C1-3 alkyl group which may be substituted with 1 to 3 halogen atoms, b) a C1-3 alkoxy group which may be substituted with 1 to 3 halogen atoms, c) a cyano group, and d) a halogen atom, or
- 5) an imidazopyridyl group which may be substituted with 1 to 3 halogen atoms)
- or a salt thereof, or a co-crystal, a hydrate or a solvate thereof.
13 more elements
Dependencies are inferred from the claim text.