Substituted pyrrolidine amides iii

A compound according to general formula (I),

• wherein
• R1 represents phenyl;
• —C1-6-alkylene-phenyl;
• 5 or 6-membered heteroaryl;
• —C1-6-alkylene-(5 or 6-membered heteroaryl) or —C1-10-alkyl;
• R1′ represents H;
• —C1-10-alkyl;
• or —C3-10-cycloalkyl;
• R2 represents —C(═O)—C1-10-alkyl;
• —C(═O)—C3-10-cycloalkyl;
• —C(═O)—C1-6-alkylene-C3-10-cycloalkyl;
• —C(═O)-(3 to 7 membered heterocycloalkyl);
• —C(═O)—C1-6-alkylene-(3 to 7 membered heterocycloalkyl);
• —C(═O)-phenyl;
• —C(═O)—C1-6-alkylene-phenyl;
• —C(═O)-(5 or 6-membered heteroaryl);
• —C(═O)—C1-6-alkylene-(5 or 6-membered heteroaryl);
• —S(═O)1-2—C3-10-cycloalkyl;
• —S(═O)1-2—C1-6-alkylene-C3-10-cycloalkyl;
• —S(═O)1-2-(3 to 7 membered heterocycloalkyl);
• —S(═O)1-2—C1-6-alkylene-(3 to 7 membered heterocycloalkyl);
• —S(═O)1-2-phenyl;
• —S(═O)1-2—C1-6-alkylene-phenyl;
• —S(═O)1-2-(5 or 6-membered heteroaryl);
• or —S(═O)1-2—C1-6-alkylene-(5 or 6-membered heteroaryl);
• R3 and R3′ independently from one another represent H;
• F;
• Cl;
• —C1-10-alkyl;
• —C3-6-cycloalkyl;
• —CH2—C3-6-cycloalkyl;
• 3 to 7 membered heterocycloalkyl;
• —CH2-(3 to 7 membered heterocycloalkyl);
• —CH2-phenyl;
• or —CH2-(5 or 6-membered heteroaryl);
• or R3 and R3′ together with the carbon atom to which they are bound form a C3-10-cycloalkyl;
• or 3 to 7 membered heterocycloalkyl;
• R4 represents -phenyl;
• —C1-6-alkylene-phenyl;
• -5 or 6-membered heteroaryl;
• or —C1-6-alkylene-(5 or 6-membered heteroaryl);
• A, X, Y and Z independently from one another represent N or CH;
• wherein at least one of R1′, R3 and R3′ is not H;
• wherein —C1-10-alkyl and —C1-6-alkylene- in each case independently from one another is linear or branched, saturated or unsaturated;
• wherein —C1-10-alkyl, —C1-6-alkylene-, —C3-10-cycloalkyl and 3 to 7 membered heterocycloalkyl in each case independently from one another are unsubstituted or mono- or polysubstituted with one or more substituents selected from —F;
• —Cl;
• —Br;
• —I;
• —CN;
• —CF3;
• —CF2H;
• —CFH2;
• —CF2Cl;
• —CFCl2;
• —C(═O)—C1-6-alkyl;
• —C(═O)—OH;
• —C(═O)—OC1-6-alkyl;
• —C(═O)—NH2;
• —C(═O)—NH(C1-6-alkyl);
• —C(═O)—N(C1-6-alkyl)2;
• —OH;
• ═O;
• —OCF3;
• —OCF2H;
• —OCFH2;
• —OCF2Cl;
• —OCFCl2;
• —O—C1-6-alkyl;
• —O—C(═O)—C1-6-alkyl;
• —O—C(═O)—O—C1-6-alkyl;
• —O—(CO)—NH(C1-6-alkyl);
• —O—C(═O)—N(C1-6-alkyl)2;
• —O—S(═O)2—NH2;
• —S(═O)2—NH(C1-6-alkyl);
• —O—S(═O)2—N(C1-6-alkyl)2;
• —NH2;
• —NH(C1-6-alkyl);
• —N(C1-6-alkyl)2;
• —NH—C(═O)—C1-6-alkyl;
• —NH—C(═O)—O—C1-6-alkyl;
• —NH—C(═O)—NH2;
• —NH—C(═O)—NH(C1-6-alkyl);
• —NH—C(═O)—N(C1-6-alkyl)2;
• —N(C1-6-alkyl)-C(═O)—C1-6-alkyl;
• —N(C1-6-alkyl)-C(═O)—O—C1-6-alkyl;
• —N(C1-6-alkyl)-C(═O)—NH2;
• —N(C1-6-alkyl)-C(═O)—NH(C1-6-alkyl);
• —N(C1-6-alkyl)-C(═O)—N(C1-6-alkyl)2;
• —NH—S(═O)2OH;
• NH—S(═O)2—C1-6-alkyl;
• —NH—S(═O)2—O—C1-6-alkyl;
• —NH—S(═O)2—NH2;
• —NH—S(═O)2—NH(C1-6-alkyl);
• —NH—S(═O)2N(C1-6-alkyl)2;
• —N(C1-6-alkyl)-S(═O)2—OH;
• —N(C1-6-alkyl)-S(═O)2—C1-6-alkyl;
• —N(C1-6-alkyl)-S(═O)2—O—C1-6-alkyl;
• —N(C1-6-alkyl)-S(═O)2—NH2;
• —N(C1-6-alkyl)-S(═O)2—NH(C1-6-alkyl);
• —N(C1-6-alkyl)-S(═O)2—N(C1-6-alkyl)2;
• —SCF3;
• —SCF2H;
• —SCFH2;
• —S—C1-6-alkyl;
• —S(═O)—C1-6-alkyl;
• —S(═O)2—C1-6-alkyl;
• —S(═O)2—OH;
• —S(═O)2—O—C1-6-alkyl;
• —S(═O)2—NH2;
• —S(═O)2—NH(C1-6-alkyl);
• —S(═O)2—N(C1-6-alkyl)2;
• —C3-6-cycloalkyl;
• 3 to 6-membered heterocycloalkyl;
• phenyl;
• 5 or 6-membered heteroaryl;
• —O—C3-6-cycloalkyl;
• —O-(3 to 6-membered heterocycloalkyl);
• —O-phenyl;
• —O-(5 or 6-membered heteroaryl);
• —C(═O)—C3-6-cycloalkyl;
• —C(═O)-(3 to 6-membered heterocycloalkyl);
• —C(═O)-phenyl;
• —C(═O)-(5 or 6-membered heteroaryl);
• —S(═O)2—(C3-6-cycloalkyl);
• —S(═O)2-(3 to 6-membered heterocycloalkyl);
• —S(═O)2-phenyl or —S(═O)2-(5 or 6-membered heteroaryl);
• wherein phenyl and 5 or 6-membered heteroaryl in each case independently from one another are unsubstituted or mono- or polysubstituted with one or more substituents selected from —F;
• —Cl;
• —Br;
• —I;
• —CN;
• —C1-6-alkyl;
• —CF3;
• —CF2H;
• —CFH2;
• —CF2Cl;
• —CFCl2;
• —C1-4-alkylene-CF3;
• —C1-4-alkylene-CF2H;
• —C1-4-alkylene-CFH2;
• —C(═O)—C1-6-alkyl;
• —C(═O)—OH;
• —C(═O)—OC1-6-alkyl;
• —C(═O)—NH(OH);
• —C(═O)—NH2;
• —C(═O)—NH(C1-6-alkyl);
• —C(═O)—N(C1-6-alkyl)2;
• —OH;
• ═O;
• —OCF3;
• —OCF2H;
• —OCFH2;
• —OCF2Cl;
• —OCFCl2;
• —O—C1-6-alkyl;
• —O—C3-6-cycloalkyl;
• —O-(3 to 6-membered heterocycloalkyl);
• —NH2;
• —NH(C1-6-alkyl);
• —N(C1-6-alkyl)2;
• —NH—C(═O)—C1-6-alkyl;
• —N(C1-6-alkyl)-C(═O)—C1-6-alkyl;
• —NH—C(═O)—NH2;
• —NH—C(═O)—NH(C1-6-alkyl);
• —NH—C(═O)—N(C1-6-alkyl)2;
• —N(C1-6-alkyl)-C(═O)—NH(C1-6-alkyl);
• —N(C1-6-alkyl)-C(═O)—N(C1-6-alkyl)2;
• —NH—S(═O)2—C1-6-alkyl;
• —SCF3;
• —S—C1-6-alkyl;
• —S(═O)—C1-6-alkyl;
• —S(═O)2—C1-6-alkyl;
• —S(═O)2—NH2;
• —S(═O)2—NH(C1-6-alkyl);
• —S(═O)2—N(C1-6-alkyl)2;
• —C3-6-cycloalkyl;
• —C1-4-alkylene-C3-6-cycloalkyl;
• 3 to 6-membered heterocycloalkyl;
• —C1-4-alkylene-(3 to 6-membered heterocycloalkyl);
• phenyl or 5 or 6-membered heteroaryl;
• in the form of the free compound or a physiologically acceptable salt thereof;
• with the proviso that the following compounds are excluded:
• N-[(2R,3S)-4,4-Dimethyl-1-[1-(1-methyl-6-oxo-1H-pyridin-3-yl)-1H-indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]-cyclopropanecarboxylic acid amide;
• N-[(2S,3R)-4,4-Dimethyl-1-[1-(1-methyl-6-oxo-1H-pyridin-3-yl)-1H-indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]-cyclopropanecarboxylic acid amide;
• N-[(2S,3R)-4,4-Dimethyl-1-[1-(1-methyl-6-oxo-1H-pyridin-3-yl)-1H-indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]-1-methyl-1H-pyrazole-3-carboxylic acid amide;
• N-[(2S,3R)-4,4-Dimethyl-1-[1-(1-methyl-6-oxo-1H-pyridin-3-yl)-1H-indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]-5-methyl-[1,2,4]oxadiazole-3-carboxylic acid amide;
• N-[(2S,3R)-4,4-Dimethyl-1-[1-(1-methyl-6-oxo-1H-pyridin-3-yl)-1H-indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]-4-methyl-thiazole-5-carboxylic acid amide;
• N-[(2S,3R)-4,4-Dimethyl-1-[1-(1-methyl-6-oxo-1H-pyridin-3-yl)-1H-indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]-thiazole-4-carboxylic acid amide;
• and
• N-[(2S,3R)-4,4-Dimethyl-1-[1-(1-methyl-6-oxo-1H-pyridin-3-yl)-1H-indazol-5-yl]-5-oxo-2-phenyl-pyrrolidin-3-yl]-5-methyl-thiazole-4-carboxylic acid amide.