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US 2022/0089549 A1Published application
Inhibitors of protein arginine deiminases (pads) and methods of preparation and use thereof
AssigneeUniversity of Massachusetts
InventorsPaul R. Thompson, Aaron Muth, Venkataraman Subramanian
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Abstract
The invention provides novel inhibitors or inactivators of protein arginine deiminases, pharmaceutical compositions and methods of use thereof. The invention also relates to molecular probes based on such compounds and methods of use thereof.
Claims16
1-37. (canceled)
A molecular imaging probe having the structural formula:
- AF-LF-W (II)
- wherein
- AF is a group comprising an optically detectable moiety;
- LF is a linking group;
- and
- W is group comprising a benzimidazole moiety, or a derivative or analog thereof, capable of inhibiting or inactivating a biological function of a protein arginine deiminase.
3 more elements
Dependencies are inferred from the claim text.