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US 2022/0089541 A1Published application
Compounds for the Treatment of Kinase-Dependent Disorders
AssigneeExelixis, Inc.
InventorsLynne Canne Bannen, Faming Jiang, Kin Tso, Xu Wei
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Abstract
The present invention relates to compounds that modulate cellular activities such as proliferation, differentiation, programmed cell death, migration, and chemoinvasion, by modulating protein kinase enzymatic activity, and compositions thereof, and methods of using such compounds.
Claims55
A compound according to formula I′:
- or a pharmaceutically acceptable salt thereof, wherein
- A is a C1-6 alkoxy, or C(O)NR7R8;
- R1 is C1-6 alkyl or heterocycloalkyl-C1-6 alkylene-;
- R2 is halo;
- R3 is halo, OH, C1-4 alkoxy, or CF3;
- R4 is halo;
- one of R5 and R6 is —CHR′R″ and the other of R5 and R6 is H or —CHR′R″;
- R7 and R8 are each independently H or a C1-6 alkyl;
- each of R′ and R″ is independently selected from the group consisting of H, OH and C1-6 alkoxy;
- Q1, Q2, and Q3 are each independently CH or N;
- x is 0, 1, 2, 3, or 4;
- y is 0, 1, 2, 3, or 4;
- and
- z is 0, 1, 2, 3, 4, or 5.
11 more elements
A compound of Formula I
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is C1-6 alkyl or heterocycloalkyl-C1-6 alkylene-;
- R2 is halo;
- R3 is halo, OH, C1-4 alkoxy, or CF3;
- R4 is halo;
- one of R5 and R6 is —CHR′R″ and the other of R5 and R6 is H or —CHR′R″;
- each of R′ and R″ is independently selected from the group consisting of H, OH and C1-6 alkoxy;
- Q1 and Q2 are each independently CH or N;
- x is 0, 1, 2, 3, or 4;
- y is 0, 1, 2, 3, or 4;
- and
- z is 0, 1, 2, 3, 4, or 5.
9 more elements
Dependencies are inferred from the claim text.