Glass-ceramics based on lithium disilicate, zircon, and apatite

A glass-ceramic precursor glass composition comprising a source of:

• 50 to 75 wt. % SiO2,
• 1 to 5 wt. % Al2O3,
• 0.5 to 10 wt. % P2O5,
• 1 to 15 wt. % CaO,
• 5 to 20 wt. % Li2O,
• 0 to 5 wt. % Na2O,
• 0.5 to 20 wt. % ZrO2, and
• 0.1 to 1.0 wt. % F−, based on a 100 wt. % total of the composition.

A method of making a glass-ceramic composition, comprising:

• ceramming a precursor glass mixture comprising a source of:
• 50 to 75 wt. % SiO2,
• 1 to 5 wt. % Al2O3,
• 0.5 to 10 wt. % P2O5,
• 1 to 15 wt. % CaO,
• 5 to 20 wt. % Li2O,
• 0 to 5 wt. % Na2O,
• 0.5 to 20 wt. % ZrO2, and
• 0.1 to 1.0 wt. % F−, based on a 100 wt. % total of the composition, by heating the mixture at 600 to 800° C. for 0.5 to 10 hrs, and then heating at 850 to 950° C. for 0.5 to 20 hrs.

A bioactive composition, comprising:

• a glass-ceramic composition comprising:
• a first crystalline phase including lithium disilicate;
• a second crystalline phase comprising at least one of:
• zircon, zirconia, apatite, or a combination thereof;
• and
• at least one live osteoblast cell.