Tangential Viral Filtration
AssigneeGenzyme Corporation
InventorsTarl Vetter, Kevin Brower
Life of this patent
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Abstract
Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.
Claims20
A method for removing viral particles from a solution, the method comprising:
- (a) transporting a solution comprising viral particles through a filter unit;
- (b) capturing a portion of the solution that passes through a filter member in a direction orthogonal to a flow direction of the transported solution through the filter unit;
- (c) transporting a remaining portion of the solution that does not pass through the filter member into a reservoir;
- (d) recirculating a portion of the solution from the reservoir through the filter unit;
- and
- (e) repeating steps (b)-(d) to capture multiple portions of the solution, where each captured solution passes through the filter member,
- wherein the filter member has a thickness and comprises a plurality of channels, and wherein for each of at least 50% of the channels in the filter member, a channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to a thickness direction of the filter member.
Dependencies are inferred from the claim text.