Fabrication of aquaporin-based biomimetic membrane
AssigneeNanyang Technological University
InventorsRong Wang, Saren Qi, Ye Li
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Abstract
Methods of fabricating a membrane comprising proteoliposomes having protein water channels are provided herein. The method may include providing a porous substrate, depositing a solution containing proteoliposomes on the porous substrate, and then contacting the porous substrate with an aqueous monomer solution and an organic monomer solution to form a selective layer on the porous substrate embedding the proteoliposomes. The method may include depositing the aqueous monomer solution, then the solution containing the proteoliposomes, then the organic monomer solution, to form the selective layer. The present disclosure also describes the membrane and a system operable to accommodate both methods.
Claims30
A method of fabricating a membrane comprising proteoliposomes having protein water channels, the method comprising:
- providing a porous substrate;
- depositing a solution on the porous substrate, wherein the solution comprises the proteoliposomes;
- and
- contacting the porous substrate with an aqueous monomer solution and an organic monomer solution to form a selective layer on the porous substrate embedding the proteoliposomes, wherein the solution is deposited prior to contacting the porous substrate with the aqueous monomer solution and the organic monomer solution.
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A method of fabricating a membrane comprising proteoliposomes having protein water channels, the method comprising:
- providing a porous substrate;
- contacting the porous substrate with an aqueous monomer solution;
- depositing a solution on the porous substrate, wherein the solution comprises the proteoliposomes;
- and
- contacting the porous substrate with an organic monomer solution to form a selective layer on the porous substrate embedding the proteoliposomes, wherein the solution is deposited after contacting the porous substrate with the aqueous monomer solution but prior to contacting the porous substrate with the organic monomer solution.
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A membrane comprising:
- a porous substrate comprising proteoliposomes deposited thereon, wherein the proteoliposomes have protein water channels incorporated therein;
- and
- a selective layer formed on the porous substrate, wherein the proteoliposomes are embedded in the selective layer.
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Dependencies are inferred from the claim text.