Nucleic Acid-Drug Conjugate, Drug Delivery System, Preparation Method Therefor and Use Thereof
AssigneeShanghai Jiaotong University
InventorsChuan Zhang, Jiao Zhang, Yuanyuan Guo
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Abstract
Disclosed are a nucleic acid-drug conjugate based on a phosphorothioate-modified nucleic acid, a drug delivery system, and a preparation method therefor. The nucleic acid-drug conjugate is formed by reacting and conjugating a phosphorothioate group in a phosphorothioate-modified nucleic acid with a group that is modified on a drug molecule and able to undergo electrophilic reaction with the phosphorothioate groups; in addition, by selecting different nucleic acid sequences including functional nucleic acids, the nucleic acid-drug conjugate is able to be self-assembled into various forms of drug-containing nano-carriers for drug delivery.
Claims21
A nucleic acid-drug conjugate based on a phosphorothioate-modified nucleic acid, wherein comprising a phosphorothioate-modified nucleic acid skeleton and a drug molecule grafted onto the nucleic acid skeleton, and the grafting is realized by reacting the phosphorothioate groups on the nucleic acid skeleton with a group modified on the drug molecule that able to undergo electrophilic reaction with the phosphorothioate groups.
21-24. (canceled)
Dependencies are inferred from the claim text.