Viscosity reduction of highly concentrated protein formulations
AssigneeMerck Patent GmbH
InventorsMartin ZILLMANN, Alexandra KROG, Raphael GUEBELI, Tanja HENZLER, Christian HILDEBRANDT
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Abstract
The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity. The contained proteins in the prepared formulations are stabilized against aggregation and denaturation and are thus sufficiently storage-stable until administration to the patient
Claims33
A method for reducing the viscosity of a liquid formulation comprising a pharmaceutically active protein in a concentration in the range of at least 50 mg/ml up to 300 mg/ml, comprising the step of combining the protein solution with a viscosity-reducing concentration of an excipient selected from the group consisting of the meglumine, ornithine, carnitine, benzenesulfonic acid and sodium p-toluene sulfonic acid, gluconic acid, glucuronic acid, aminocaproic acid and succinate or mixtures thereof.
Dependencies are inferred from the claim text.