Genomic variants in ig gene regions and uses of same
OwnerWayne A. Marasco, Corey Watsoninventors
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Abstract
The present invention is directed to methods for mining genotype-repertoire-disease associations. Aspects of the disclosure are also drawn to methods of preparing a vaccine composition. For example, the vaccine composition can be specific to a subject or a group of subjects with a genotype responsive to the vaccine composition. Aspects of the disclosure are further drawn towards methods of vaccinating a subject or a population of subjects.
Claims16
A method of preparing a vaccine composition specific to a subject with a genotype responsive to the vaccine composition, comprising the steps of:
- obtaining a biological sample from the subject;
- identifying germ-line polymorphisms at a immunoglobulin (IG) loci in the tissue sample;
- identifying antibody repertoire in the tissue sample;
- comparing the germ-line polymorphisms to the antibody repertoire to identify the subject as responsive to a vaccine composition;
- and
- preparing a vaccine composition specific for the subject.
A method of vaccinating a subject, the method comprising the steps of:
- obtaining a biological sample from the subject;
- identifying germ-line polymorphisms at a immunoglobulin (IG) loci in the tissue sample;
- identifying antibody repertoire in the tissue sample;
- comparing the germ-line polymorphisms to the antibody repertoire to identify the subject as responsive to a vaccine composition;
- and
- administering the vaccine composition to the subject.
A method of identifying a subject as responsive to a vaccine composition, comprising the steps of:
- obtaining a biological sample from the subject;
- identifying germ-line polymorphisms at a immunoglobulin (IG) loci in the tissue sample;
- comparing the germ-line polymorphisms in the tissue sample to known germ-line polymorphisms, wherein the known germ-line polymorphisms are indicative of responsiveness to the vaccine composition;
- and
- identifying the subject as responsive to the vaccine composition if the subject's germ-line polymorphisms are similar to the known germ-line polymorphisms.
A method of vaccine discovery, the method comprising the steps of:
- obtaining biological samples from a population of subjects;
- identifying germ-line polymorphisms at a immunoglobulin (IG) loci in the tissue samples;
- identifying the antibody repertoire in the tissue samples;
- comparing the germ-line polymorphisms to the antibody repertoires to identify a population as responsive to a vaccine composition.
Dependencies are inferred from the claim text.