Compositions and methods for treating necrotizing enterocolitis
AssigneeEmpire Biotechnologies, Inc.
InventorDonald Adam McCarthy
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Abstract
The invention provides compositions and methods for treating NEC by promoting weight gain and reducing intestinal inflammation by agonizing intestinal v 3 and v 5 and/or gastric 8 1 integrins. In particular, the invention relates to treating NEC with Milk Fat Globule EGF-like 8 (Mfge8) also known as human Lactadherin.
Claims22
A method for treating or preventing necrotizing enterocolitis (NEC) in a human infant, comprising orally administering an agonist for an αvβ3, αvβ5, or an α8β1 integrin receptor in intestinal enterocytes of said human infant.
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A use of an agonist for an αvβ3, αvβ5, or α8β1 integrin receptor for treating necrotizing enterocolitis (NEC) in a human infant.
Dependencies are inferred from the claim text.