Composition for treating blood coagulation and/or complement disorders
AssigneesPublic University Corporation Yokohama City University, Takeda Pharmaceutical Company Limited
InventorsTakanori TAKEBE, Norikazu SAIKI, Eri KAWAKAMI
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Abstract
The present invention provides a composition suitable as a composition for treating blood coagulation and/or complement disorders (raw materials for producing therapeutic agents for these diseases) and a method for effectively producing the composition. A method for producing a composition for treating blood coagulation and/or complement disorders according to the present invention includes the following steps of: (1) embedding an organoid formed from vascular endothelial cells or vascular endothelial cells and hepatocytes, in an extracellular matrix; (2) culturing the extracellular matrix; and (3) collecting a culture supernatant from the culture obtained in the step (2).
Claims4
A method for producing a composition for treating blood coagulation and/or complement disorders, comprising the following steps of:
- (1) embedding an organoid formed from
- vascular endothelial cells or
- vascular endothelial cells and hepatocytes, in an extracellular matrix;
- (2) culturing the extracellular matrix;
- and
- (3) collecting a culture supernatant from the culture obtained in step (2).
A composition for treating blood coagulation and/or complement disorders, comprising two or more components selected from:
- 10×10−6 wt % to 1000×10−6 wt % of factor II,
- 0.1×10−6 wt % to 10×10−6 wt % of factor V,
- 0.1×10−6 wt % to 10×10−6 wt % of factor VII,
- 1×10−6 wt % to 100×10−6 wt % of factor VIII,
- 0.1×10−6 wt % to 10×10−6 wt % of factor IX,
- 0.1×10−6 wt % to 10×10−6 wt % of factor X,
- 0.01×10−6 wt % to 1×10−6 wt % of factor XI,
- 1×10−6 wt % to 100×10−6 wt % of antithrombin,
- 10×10−6 wt % to 1000×10−6 wt % of complement component 3 (C3),
- 10×10−6 wt % to 100×10−6 wt % of complement component 5 (C5),
- 10×10−6 wt % to 100×10−6 wt % of Factor B (FB), and
- 100×10−6 wt % to 1000×10−6 wt % of Factor H (FH).
Dependencies are inferred from the claim text.