Metabolite encapsulating nanoparticles to enhance cellular cancer immunotherapy
AssigneeTechnion Research & Development Foundation Limited
InventorsTomer SHLOMI, Abraham RUTENBERG
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Abstract
Provided herein are nanoparticles encapsulating a required substance for enriching immune cells with the required substance, compositions comprising the same and methods for their preparation. Further provided are methods of using the nanoparticles for enriching the immune cells with the required substance as well as methods of treating cancer using the nanoparticles or compositions comprising the same.
Claims22
-42. (canceled)
A method of enriching immune cells with a required substance, the method comprising the step of contacting the immune cells with a nanoparticle comprising the required substance, thereby enriching the immune cells with the required substance, wherein the required substance is a required metabolite, sugar, amino acid, nucleoside, nucleotide, ribonucleoside, ribonucleotide, nutrient, or any combination thereof.
A nanoparticle for enriching immune cells with a required substance, the nanoparticle comprising a silica shell, wherein the required substance comprises a required metabolite, sugar, amino acid, nucleoside, nucleotide, ribonucleoside, ribonucleotide, nutrient or the combination thereof.
A nanoparticle for enriching immune cells with sugar and/or an amino acid, the nanoparticle comprising a shell capable of encapsulating the sugar and/or the amino acid, wherein the nanoparticle is coated by or attached to one or more immune cell targeting agents, wherein the one or more targeting agent is selected from an antibody, peptide, aptamer, heptamer, oligomer, targeting vector or nanobody.
Dependencies are inferred from the claim text.