A stable cardioplegic solution for cardiac surgery
AssigneeNational Taiwan University
InventorsYih-Sharng Chen, Li-Jiuan Shen, Mei-Hsin Lin, Heng-Wen Chou
Life of this patent
Estimating the term…
Abstract
The present invention is a cardioplegic solution that demonstrates better stability in pH, particulate matter formation and osmolality but at the same time demonstrates superior ability to preserve heart functions than currently available cardioplegic solutions. The cardioplegic solution comprises potassium (K+), magnesium (Mg2+), sodium (Na+), chloride (Cl−), gluconate, acetate, sulfate (SO42−), THAM and mannitol dissolved in water.
Claims24
A cardioplegic solution comprising potassium (K+), magnesium (Mg2+), sodium (Na+), chloride (Cl−), gluconate, acetate, sulfate (SO42−), THAM and mannitol dissolved in water, wherein the potassium (K+) concentration is about 27 to about 33 mEq/L, the magnesium (Mg2+) concentration is about 16 to about 20 mEq/L, the sodium (Na+) concentration is about 120 to about 146 mEq/L, the chloride (Cl−) concentration is about 106 to about 130 mEq/L, the gluconate concentration is about 20 to about 24 mmol/L, the acetate concentration is about 22 to about 28 mmol/L, the sulfate (SO42−) concentration is about 6 to about 9 mmol/L, the THAM concentration is between about 5 to about 30 mmol/L and mannitol concentration is about 2 to about 5 g/L.
Dependencies are inferred from the claim text.