Inorganic Nitrite to Improve Cardiopulmonary Hemodynamics
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsMark Thomas Gladwin, Edwin Parsley, Hunter Clay Champion
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Abstract
Disclosed herein are methods for treating acute or chronic heart failure using inorganic nitrite, such as sodium nitrite. The method includes administering to a subject in need of treatment a therapeutically effective amount of inorganic nitrite. The nitrite may be administered by inhalation and may be nebulized. The nitrite may be administered at an emitted dose or in an escalated titrated dose. The nitrite may be a liquid formulation or a dry powder formulation.
Claims18
A method of decreasing one or more of pulmonary capillary wedge pressure, right atrial pressure and pulmonary arterial pressure in a subject in need thereof, the method comprising administering, by inhalation, a therapeutically effective dose of inorganic nitrite in an escalated titrated dose, wherein such administration does not cause a significant drop in blood pressure and increase in heart rate.
Dependencies are inferred from the claim text.