Substituted phenyl boronic acid containing polymers and methods of use

A pharmaceutical composition comprising a polymer that comprises a repeat unit of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein,
• R1, R2, and R3 are each independently hydrogen, or substituted or unsubstituted alkyl;
• Y1 is a direct bond or —NR9—;
• Z is
• wherein the —B(OH)2 is at the 3- or 4-position of the phenyl ring with respect to Y1;
• X1 and X2 are each independently selected from a group consisting of hydrogen, halo, and —CF3, with the proviso that no more than one of X1 and X2 is hydrogen;
• R9 in each occurrence is hydrogen, or substituted or unsubstituted alkyl;
• n is an integer from 1 to 100,000;
• and
• m is an integer from 1 to 4;
• and
• optionally one or more of an excipient, adjuvant, binder, diluent, disintegrant, filler, or lubricant;
• and wherein the pharmaceutical composition is for oral administration.

A pharmaceutical composition comprising a polymer that comprises the structure:

• or a pharmaceutically acceptable salt thereof, wherein:
• X1 and X2 are each independently selected from a group consisting of hydrogen, halo, and —CF3, with the proviso that no more than one of X1 and X2 is hydrogen;
• and
• each n and m are independently an integer from 1 to 100,000,
• wherein co denotes copolymer;
• and
• optionally one or more of an excipient, adjuvant, binder, diluent, disintegrant, filler, or lubricant;
• and wherein the pharmaceutical composition is for oral administration.

A pharmaceutical composition comprising a polymer that comprises a structure selected from the group consisting of:

• and pharmaceutically acceptable salts thereof, wherein co denotes copolymer;
• and
• optionally one or more of an excipient, adjuvant, binder, diluent, disintegrant, filler, or lubricant;
• and wherein the pharmaceutical composition is for oral administration.