A sustained release composition comprising a hydroxyalkyl methylcellulose
AssigneeDdp Specialty Electronic Materials US, LLC
InventorOliver Petermann
Life of this patent
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Abstract
A sustained release composition for oral administration comprises particles of a physiologically active ingredient mixed with a hydroxyalkyl methylcellulose, wherein the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl, the hydroxyalkyl methylcellulose has an MS(hydroxyalkyl) of 0.05 to 1.00, and hydroxy groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.30 or less, and wherein the concentration of hydroxyalkyl methylcellulose is 0.1-10% by dry weight of the active ingredient.
Claims15
A sustained release composition for oral administration comprising particles of a physiologically active ingredient mixed with a hydroxyalkyl methylcellulose, wherein the ether substituents are methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl,
- the hydroxyalkyl methylcellulose has an MS(hydroxyalkyl) of 0.05 to 1.00, and
- hydroxy groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.30 or less,
- wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups,
- wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups, and
- wherein the concentration of hydroxyalkyl methylcellulose is 0.1-10% by dry weight of the active ingredient.
Dependencies are inferred from the claim text.