Compositions and uses thereof for treatment of idiopathic preterm birth
AssigneeUniversity of South Florida
InventorsCharles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Ali Kayisli, Frederick Schatz
Life of this patent
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Abstract
Disclosed are compositions and methods for delaying or preventing idiopathic preterm birth.
Claims18
A method of delaying or preventing idiopathic preterm birth in a subject, comprising administering to the subject a therapeutically effective amount of a composition comprising 15-deoxy-Δ12,14-prostaglandin J2, 9-nitro-9E-octadecenoic acid, 10-nitro-9E-octadecenoic acid or a derivative thereof or a combination thereof.
A method of delaying or preventing an idiopathic preterm birth in a subject, comprising
- a) determining whether a biological sample obtained from the subject has an increased level of FKBP51 as compared to a control;
- and
- b) administering to the subject a therapeutically effective amount of a composition comprising 15-deoxy-Δ12,14-prostaglandin J2, 9-nitro-9E-octadecenoic acid, 10-nitro-9E-octadecenoic acid, or a derivative thereof, or a combination thereof if the biological sample obtained from the subject has an increased level of FKBP51 as compared to the control.
A method of delaying or preventing an idiopathic preterm birth in a subject, comprising
- a) determining whether a biological sample obtained from the subject has an altered level of 9-nitro-9E-octadecenoic acid or 10-nitro-9E-octadecenoic acid as compared to a control;
- and
- b) administering to the subject a therapeutically effective amount of a composition comprising 15-deoxy-Δ12,14-prostaglandin J2 or a derivative thereof if the biological sample obtained from the subject has an altered level of 9-nitro-9E-octadecenoic acid or 10-nitro-9E-octadecenoic acid as compared to the control.
Dependencies are inferred from the claim text.