Methods of treating tyrosine kinase inhibitor-induced diarrhea

A method of:

• treating a subject with tyrosine kinase inhibitor-induced diarrhea;
• reducing intestinal fluid secretion resulting from tyrosine kinase inhibitor-induced activation of potassium channels or tyrosine kinase inhibitor-induced activation of CFTR chloride channels in the intestinal epithelium in a subject in need thereof;
• reducing tyrosine kinase inhibitor-induced potassium channel current or tyrosine kinase inhibitor-induced CFTR chloride channel current in the intestinal epithelium of a subject in need thereof;
• or
• treating diarrhea in a subject being administered a tyrosine kinase inhibitor wherein the method comprises determining whether the diarrhea is tyrosine kinase inhibitor-induced diarrhea;
• said method comprising administering to said subject a potassium channel inhibitor, or a CFTR chloride channel inhibitor, or a combination of a potassium channel inhibitor and CFTR chloride channel inhibitor.