Fused thiophene compounds

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein
• Q1, Q2, and Q3, are independently CR1, CR2, or —S—;
• wherein one of Q1, Q2, and Q3 is —S—;
• one of Q1, Q2, and Q3 is CR1;
• and one of Q1, Q2, and Q3 is CR2;
• each - - - is a carbon-carbon single bond, a carbon-carbon double bond, or a carbon-sulfur single bond;
• R1 is H, deuterium, hydroxyl, halogen, cyano, nitro, optionally substituted C1-C6 alkoxy, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, optionally substituted amino, C1-C6 alkylamino, amino(C1-C6 alkyl), (C1-C6 alkoxy)C1-C6 alkyl, —O—(C1-C6 alkoxy)C1-C6 alkyl, or optionally substituted C3-C8 carbocyclyl;
• R2 is
• R3 is H, deuterium, an optionally substituted C1-C6 alkyl,
• X is C═O, CHR4A, or CR4AR4B;
• each R4A and R4B is independently H, deuterium, or C1-C6 alkyl;
• X1 is H, deuterium, fluoro, or C1-C6 alkyl;
• each of XA, XB, and XC is independently a bond, (CH2)m, (CF2)m, O, S, and NH;
• wherein none of XA—XB, XA—XC, or XB—XC is a bond selected from N—N, N—O, N—S, O—N, S—N, O—O, S—S, or N═N;
• wherein, not more than one of XA, XB, and XC can be a bond;
• and wherein any hydrogen of the (CH2)m and NH groups can be substituted by one or more R5;
• R5 is hydrogen, deuterium, halogen, C1-C6 alkyl, or C1-C6 haloalkyl;
• m is 1, 2, or 3;
• n is 0, 1, or 2;
• R6 is C6-C10 aryl, 5 to 10 membered heteroaryl, C3 to C8 carbocyclyl, or 3 to 10 membered heterocyclyl, each optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxyl, optionally substituted C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, (C1-C6 alkoxy)C1-C6 alkyl, —O—(C1-C6 alkoxy)C1-C6 alkyl, C1-C6 alkylamino, amino(C1-C6 alkyl), —C(═O)NR16aR16b, optionally substituted C3-C7 cycloalkyl, optionally substituted C3-C7 cycloalkyl(C1-C6 alkyl), optionally substituted C6-C10 aryl, optionally substituted C6-C10 aryl(C1-C6 alkyl), optionally substituted 5 to 10 membered heteroaryl, optionally substituted 5 to 10 membered heteroaryl(C1-C6 alkyl), optionally substituted heterocyclyl, and optionally substituted heterocyclyl(C1-C6 alkyl);
• each R16a and R16b is independently H or C1-C6 alkyl, or R16a and R16b together with the nitrogen atom to which they are attached form 5 or 6 membered heterocyclyl optionally substituted with one or more R9;
• each R9 is independently C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, (C1-C6 alkoxy)C1-C6 alkyl, —O—(C1-C6 alkoxy)C1-C6 alkyl, optionally substituted amino, halogen, or cyano;
• or two geminal R9 form oxo (═O);
• and
• each of R10, R11, R12, R13, R14, and R15 is independently H, an optionally substituted C1-C6 alkyl, or C3-C6 cycloalkyl;
• or R14 and R15 together with the nitrogen atom to which they are attached form an optionally substituted 5 or 6 membered heterocyclyl.