Methods for treating cancer using tozadenant

A unit dosage pharmaceutical composition comprising about 0.5 to about 1.0 mg of tozadenant or a molar-equivalent amount thereof of a pharmaceutically acceptable salt of tozadenant, and a pharmaceutically acceptable carrier.

A method of treating cancer in a human patient in need thereof, said method comprising orally administering to the patient an amount of tozadenant or a pharmaceutically acceptable salt thereof that provides an AUC at steady state of about 71 hr*ng/mL to about 106 hr*ng/mL in the patient.

Use of a maximum daily dose in the range of about 0.5 to about 1.0 mg of tozadenant or a molar-equivalent amount thereof of a pharmaceutically acceptable salt of tozadenant for the manufacture of a medicament for treating cancer in a human patient.

Tozadenant or a pharmaceutically acceptable salt thereof for use in treating cancer in a human at a maximum daily oral dose in the range of about 0.5 to about 1.0 mg of tozadenant or a molar-equivalent amount thereof of a pharmaceutically acceptable salt of tozadenant.

A method for inhibiting metastasis of a malignant tumor in a human patient in need thereof, said method comprising orally administering to the patient a maximum daily dose in the range of about 0.5 to about 1.0 mg of tozadenant or a molar-equivalent amount thereof of a pharmaceutically acceptable salt of tozadenant.