Pac-1 combination therapy
AssigneeThe Board of Trustees of the University of Illinois
InventorsPaul J. HERGENROTHER, Jessie PEH
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Abstract
Compositions and methods for the induction of cancer cell death. The compositions and methods include use of compositions in therapy for the treatment of cancer and for the selective induction of apoptosis in cancer cells. The drug combinations described herein can be synergistic and can have lower neurotoxicity effects than the same amounts of other compounds and combinations of compounds and can be effective when a particular cancer has become resistant to previously administered therapies.
Claims20
A method of treating a cancer in a patient in need thereof comprising administering to a patient, concurrently or sequentially, a therapeutically effective amount of the compound PAC-1:
- and an effective amount of a second active agent, wherein the second active agent is an inhibitor of the BRAF enzyme that has the V600E or the V600K mutation, and the second active agent is vemurafenib, dabrafenib, or encorafenib, wherein the cancer is thereby treated.
A composition comprising the compound PAC-1 and an inhibitor of the BRAF enzyme that has the V600E or the V600K mutation.
A method of treating a cancer in a patient in need thereof comprising administering to a patient, concurrently or sequentially, a therapeutically effective amount of the compound PAC-1:
- and an effective amount of a second active agent;
- wherein the second active agent is an inhibitor of the BRAF enzyme that has the V600E or the V600K mutation;
- an administered combination of the second active agent and PAC-1 have synergistic anticancer activity;
- the second active agent is vemurafenib, dabrafenib, or encorafenib;
- the cancer is melanoma, leukemia, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, breast cancer, brain cancer, lymphoma, osteosarcoma, Erdheim-Chester disease (ECD), or Langerhans' cell histiocytosis (LCH);
- and
- the cancer is thereby treated.
Dependencies are inferred from the claim text.