Methods of treating addiction

A method for the treatment or prevention of opiate addiction relapse (e.g., for detoxification and maintenance treatment of opioid addiction or prevention of relapse to opioid addiction), comprising administering to a patient in need thereof a Compound of Formula I:

• R1 is H, C1-6alkyl, —C(O)—O—C(Ra)(Rb)(Rc), —C(O)—O—CH2—O—C(Ra)(Rb)(Rc) or —C(R6)(R7)—O—C(O)—R8;
• R2 and R3 are independently selected from H, D, C1-6alkyl (e.g., methyl), C1-6alkoxy (e.g., methoxy), halo (e.g., F), cyano, or hydroxy;
• L is C1-6alkylene (e.g., ethylene, propylene, or butylene), C1-6alkoxy (e.g., propoxy or butoxy), C2-3alkoxyC1-3alkylene (e.g., —CH2CH2OCH2—), C1-6alkylamino or N—C1-6alkyl C1-6alkylamino (e.g., propylamino or N-methylpropylamino), C1-6alkylthio (e.g., —CH2CH2CH2S—), C1-6alkylsulfonyl (e.g., —CH2CH2CH2S(O)2—), each of which is optionally substituted with one or more R4 moieties;
• each R4 is independently selected from C1-6alkyl (e.g., methyl), C1-6alkoxy (e.g., methoxy), halo (e.g., F), cyano, or hydroxy;
• Z is selected from aryl (e.g., phenyl) and heteroaryl (e.g., pyridyl, indazolyl, benzimidazolyl, benzisoxazolyl), wherein said aryl or heteroaryl is optionally substituted with one or more R4 moieties;
• R8 is —C(Ra)(Rb)(Rc), —O—C(Ra)(Rb)(Rc), or —N(Rd)(Re);
• Ra, Rb and Rc are each independently selected from H and C1-24alkyl;
• Rd and Re are each independently selected from H and C1-24alkyl;
• R6 and R7 are each independently selected from H, C1-6alkyl, carboxy and C1-6alkoxycarbonyl;
• in free or salt form (e.g., pharmaceutically acceptable salt form), for example in an isolated or purified free or salt form (e.g., pharmaceutically acceptable salt form).