Co-Administration of inhibitors to produce insulin producing gut cells
AssigneeThe Trustees of Columbia University in the City of New York
InventorsDomenico Accili, Takumi Kitamoto, Hua V. Lin
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Abstract
Methods are described for producing enteroendocrine cells that make and secrete insulin in a subject by co-administering a Foxo1 inhibitor in combination with a Notch inhibitor or ROCK inhibitor, or both. Also described are pharmaceutical compositions comprising a combination of a Foxo1 inhibitor with a Notch inhibitor or ROCK inhibitor, or both. The described methods and compositions may be used to treat a disorder associated with impaired pancreatic function such as diabetes.
Claims26
A method for treating or preventing a disease or disorder in a subject associated with impaired pancreatic function, comprising co-administering to the subject a therapeutically effective amount of a Foxo1 inhibitor and a therapeutically effective amount of a Notch inhibitor or Rock inhibitor, or both.
A pharmaceutical composition for treating or preventing a disease or disorder in a subject associated with impaired pancreatic function, comprising an effective amount of a Foxo1 inhibitor and a Notch inhibitor or ROCK inhibitor, or both.
A method for producing enteroendocrine cells that make and secrete insulin in a subject, comprising co-administering to the subject an effective amount of a Foxo1 inhibitor and an effective amount of a Notch inhibitor or Rock inhibitor, or both.
Dependencies are inferred from the claim text.