Increasing Drug Bioavailability In Naltrexone Therapy

A method of administering naltrexone and bupropion, the method comprising:

• orally administering one or more pharmaceutical compositions comprising a sustained release formulation of naltrexone or a pharmaceutically acceptable salt thereof and a sustained release formulation of bupropion or a pharmaceutically acceptable salt thereof to a patient in need thereof, wherein the amount of bupropion or pharmaceutically acceptable salt thereof is in the range of about 90 mg to about 360 mg per day, and the amount of naltrexone or pharmaceutically acceptable salt thereof is in the range of about 8 mg to about 32 mg per day, and wherein the one or more pharmaceutical compositions are administered in combination with food that is not a high-fat meal.