Small molecule promoting osteoblast differentiation
AssigneeCornell University
InventorsTodd EVANS, Brandoch COOK, Shuibing CHEN
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Abstract
Provided are compositions and methods for promoting osteogenic differentiation of undifferentiated cells, such as stem cells. An example of a compound useful in the present method is 6,8-dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one (DIPQUO). The present methods can be used for treatment and prevention of bone disorders.
Claims12
A method for preventing or treating a bone disorder in a subject in need thereof comprising administering to the subject an effective amount of a compound to prevent or treat the bone disorder, said compound having the structure:
- wherein R1, R2, R3, R4, R5, R6, R7, R8, and R9 individually at each occurrence can be —H, linear alkyl groups, branched alkyl groups, or halogens.
A pharmaceutical composition comprising one or more compounds having the structure:
- wherein R1, R2, R3, R4, R5, R6, R7, R8, and R9 individually at each occurrence can be —H, linear alkyl groups, branched alkyl groups or halogens, in a pharmaceutical carrier
A pharmaceutical composition consisting essentially of:
- (6,8-dimethyl-3-(4-phenyl-1H-imidazol-5-yl)quinolin-2(1H)-one) in a pharmaceutical carrier.
Dependencies are inferred from the claim text.