Histone acetylase p300 inhibitor and use thereof

Compound of formula (I) or a stereoisomer, a solvate or a pharmaceutically acceptable salt, or an isotope-substituted form thereof:

• Wherein, A is selected from O, N and S;
• Ry is selected from none, H, alkyl, substituted alkyl or alkenyl;
• Each of Rv, Rw, and Rx is independently selected from the group consisting of H, halogen, cyano, nitro, alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, substituted amides, substituted guanidyl, substituted carbamido, amino, substituted amino, alkoxyl, substituted alkoxyl;
• Each of R1, R2, R3, and R4 is independently selected from the group consisting of H, alkyl, halogen;
• or, for R1, R2, R3, and R4, R1 and R2 are linked to form a ring, R2 and R3 are linked to form a ring, and/or R3 and R4 are linked to form a ring;
• R5 is selected from the group consisting of alkyl, alkoxyl, amino, substituted amino, amide, substituted amides, ester group, carbonyl, heterocyclyl, substituted heterocyclyl.