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US 2022/0087995 A1Published application
4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
AssigneeTheravance Biopharma R&D IP, LLC
InventorsLori Jean Patterson, Eric L. Stangeland
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Abstract
The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Claims6
1-37. (canceled)
A process for preparing a hydrochloride salt of a compound of formula 1:
- the process comprising contacting a compound of the formula:
- with hydrochloric acid to form a hydrochloride salt of the compound of formula 1.
A process for preparing a hydrochloride salt of a compound of formula 1:
- the process comprising:
- (a) contacting acetyl chloride with ethanol to form a reaction mixture;
- and
- (b) contacting a compound of the formula:
- with the reaction mixture from step (a) to form a hydrochloride salt of the compound of formula 1.
2 more elements
Dependencies are inferred from the claim text.