A method for treating swi/snf complex-deficient cancers comprising glutathione (gsh) metabolic pathway inhibitor
AssigneesNational Cancer Center, Ono Pharmaceutical Co., Ltd.
InventorsHideaki OGIWARA, Takashi KOHNO, Hiroki SASAKI
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Abstract
The present invention provides a method for treating SWI/SNF complex-deficient cancers comprising a glutathione (GSH) metabolic pathway inhibitor, a pharmaceutical composition comprising a glutathione (GSH) metabolic pathway inhibitor for therapy in SWI/SNF complex-deficient cancers, and a glutathione (GSH) metabolic pathway inhibitor for use in treating SWI/SNF complex-deficient cancers. The present invention also provides a method for detecting and/or selecting a susceptible patient to a glutathione (GSH) metabolic pathway inhibitor.
Claims16
A method for treating SWI/SNF complex-deficient cancer, comprising administering an effective amount of a glutathione (GSH) metabolic pathway inhibitor to a mammal in need thereof.
The method according to claim 10, wherein the GSH reduction compound is APR-017 or APR-246.
A method for detecting and/or selecting a susceptible patient to a glutathione (GSH) metabolic pathway inhibitor, comprising detecting the presence of SWI/SNF complex deficiency in a patient having cancer.
A pharmaceutical composition comprising an effective amount of a glutathione (GSH) metabolic pathway inhibitor for treating SWI/SNF complex-deficient cancer.
Glutathione (GSH) metabolic pathway inhibitor for use in treating SWI/SNF complex-deficient cancer.
A kit comprising (a) a glutathione (GSH) metabolic pathway inhibitor, and (b) instructions for treating SWI/SNF complex-deficient cancer.
Dependencies are inferred from the claim text.