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US 2022/0087985 A1Published application
2-amino-3-carbonyl imidazopyridine and pyrazolopyridine compounds
Assignee1ST Biotherapeutics, Inc.
InventorsJinhwa LEE, Suyeon JO, Keonseung LIM, A Yeong PARK, Gadhe Changdev GORAKSHNATH, Hwajung NAM, Yeonguk JEON, Yejin HWANG, Jae Eun KIM, Misoon KIM, Inyoung YANG
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Abstract
The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method for treating or preventing an inflammatory and autoimmune diseases, especially neuroinflammation diseases using the compound.
Claims24
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 and R2 are independently —H, C1-C6 alkyl, C3-C6 carbocyclyl, C1-C4 alkanoyl, —(CO) C3-C6 carbocyclyl, aryl, or heteroaryl, wherein each R1 and R2 is optionally substituted with one or more groups selected from the group consisting of halo, alkyl, hydroxyalkyl, haloalkyl, and monoalkylaminoalkyl;
- or R1 and R2 together form a 5-member heterocycle;
- R3 is —H, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —O-cycloalkyl, —O-heterocyclyl, —O-aryl, —O-heteroaryl, —NRc-alkyl, —NRc-cycloalkyl, —NRc-heterocyclyl, —NRc-aryl, —NRc-heteroaryl, —NRc—NRc C(═O)Rc or —CF3, wherein R3 is optionally substituted with one or more groups selected from the group consisting of halo, alkyl, hydroxyalkyl, haloalkyl, and monoalkylaminoalkyl;
- R4 and R5 are independently —H, —OH, halo, C1-C6 alkyl, C1-C6 alkoxy, aryl, heteroaryl, heterocyclyl, heteroalkyl, amino, —SCH3, or —CN;
- R6 is selected from the group consisting of —H, halo, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 carbocyclyl, heterocyclyl, aryl, heteroaryl, —NRc-aryl, —NRc-heteroaryl, —O-aryl, —O-heteroaryl, wherein R6 is optionally substituted with one or more groups selected from the group consisting of halo, hydroxyl, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, aminoalkyl, trimethylsilylethoxymethyl, morpholinyl, piperazinyl, methylpiperazinyl, alkoxyalkenyl, —NO2, —NRaRb, —NRaC(═O)Rb, —NRaC(═O)NRaRb, —NRaC(═O)ORb, —ORa, —SRa, —CN, —C(═O)Ra, —C(═O)ORa, —C(═O)NRaRb, —OC(═O)Ra, —OC(═O)ORa, and —OC(═O)NRaRb;
- Ra and Rb are independently —H, halo, amino, alkyl, or haloalkyl;
- Rc is —H, C1-C3 alkyl, or cyclopropyl;
- and
- X is N when Y is C, or X is C when Y is N.
7 more elements
Dependencies are inferred from the claim text.