Methods for the prevention or treatment of cytokine storm
AssigneesBeth Israel Deaconess Medical Center, Inc., The Regents of the University of California
InventorsDipak PANIGRAHY, Allison GARTUNG, Anna FISHBEIN, Bruce HAMMOCK, Sung Hee HWANG, Vikas P. SUKHATME
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Abstract
The invention provides methods for treating, suppressing, or preventing detrimental cytokine and/or lipid mediator surges that can result from a variety of different diseases, conditions, and therapeutic treatments, e.g., by inhibition of cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH).
Claims25
A method of treating, suppressing, or preventing a cytokine or lipid surge in a subject, or treating, suppressing, or preventing a disease or condition caused by a cytokine or lipid surge, the method comprising administering to the subject a dual inhibitor of cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH), or an inhibitor of COX-2 and an inhibitor of sEH.
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A method of preventing, suppressing, or treating cancer in a subject, the method comprising administering to the subject a (i) chemotherapeutic or immunotherapeutic agent, and (ii) a dual inhibitor of COX-2 and sEH, or an inhibitor of COX-2 and an inhibitor of sEH, wherein optionally the chemotherapeutic or immunotherapeutic agent is an immune checkpoint inhibitor, which is optionally is an antibody against PD-1.
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A pharmaceutical composition or kit comprising a compound of Table 1 in combination with a compound of Table 2 or Table 3, or a compound of Table 2 with a compound of Table 3.
Dependencies are inferred from the claim text.