Mechanosynthesis of a Co-Amorphous Formulation of Creatine with Citric Acid and Humidity-Mediated Transformation into a Co-Crystal
AssigneeSouthern Methodist University
InventorsTomche Runchevski, Kyle B. Pekar, Jonathan B. Lefton
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Abstract
The present invention includes a co-crystal of creatine and citric acid obtained by milling, methods of making the same that include a process for the preparation of co-amorphous formulation of creatine and citric acid, the process comprising: mixing creatine and citric acid; milling the creatine and citric acid for a time sufficient to form a co-amorphous solid, which co-amorphous solid can be converted into a co-crystal, and nutritional supplements that include the same.
Claims23
A co-crystal of creatine and citric acid obtained by milling.
A process for the preparation of co-amorphous formulation of creatine and citric acid, the process comprising:
- mixing creatine and citric acid;
- milling the creatine and citric acid for a time sufficient to form a co-amorphous solid.
A process for the preparation of a co-crystal of creatine and citric acid, the process comprising:
- mixing a creatine in the form of a creatine base, a creatine anhydrate, a creatine in zwitterionic form or a creatine hydrate with molar amount of water from 0 to 5 with citric acid;
- and
- milling the creatine and citric acid for a time sufficient to form the co-crystal.
A nutritional supplement comprising co-crystal, co-amorphous, or both, of creatine and citric acid with molar ratio of water from 0 to 5.
Dependencies are inferred from the claim text.