Compositions and Methods for Treating the Eye

A method for preventing or treating the symptoms associated with dry eye comprising the step of administering a composition comprising:

• i) a safe and effective amount of a compound and/or extract having retinol-like properties and/or benefits for use in treating dry eye selected from one or more of botanical extracts, or sources of extracts, from plants of the genus Acronychia, Licaria, Calendula and or Trigonella;
• bacterial extracts, or sources of extracts, of the genus Actinomyces;
• and compounds of Formula (I):
• wherein—
• the dotted lines represent simple or double bound;
• R1 represent an H, a carbonated chain, linear, cyclic, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• R2 represent a carbonated chain, linear, cyclic ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• preferably a methyl (—CH3) or methylene (═CH2) moiety;
• a represent a carbonated chain, linear, ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• and
• ii) optionally, an ophthalmologically acceptable carrier.

A method for treating a patient having decreased or low-level production/release/delivery/excretion of hyaluronic acid from and/or in the cornea comprising the step of topically administering to the eye the patient a composition comprising:

• i) a safe and effective amount of a compound and/or extract having retinol-like properties and/or benefits for use in treating dry eye selected from one or more of:
• botanical extracts, or sources of extracts, from plants of the genus Acronychia, Licaria, Calendula and or Trigonella;
• bacterial extracts, or sources of extracts, of the genus Actinomyces;
• and compounds of Formula (I):
• wherein—
• the dotted lines represent simple or double bound;
• preferably one of the dotted line is a double bound;
• R1 represent an H, a carbonated chain, linear, cyclic, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• R2 represent a carbonated chain, linear, cyclic ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• preferably a methyl (—CH3) or methylene (═CH2) moiety;
• a represent a carbonated chain, linear, ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• preferably from 1 to 10 carbon atoms;
• more preferably 6 carbon atoms;
• preferably an aromatic moiety, preferably a phenyl moiety;
• preferably 2-methyl-prop-1,3-diene.
• ii) optionally, an ophthalmologically acceptable carrier.

A composition for treating dry eye, comprising:

• i) a safe and effective amount of a compound and/or extract having retinol-like properties and/or benefits for use in treating dry eye selected from one or more of:
• botanical extracts, or sources of extracts, from plants of the genus Acronychia, Licaria, Calendula and or Trigonella;
• bacterial extracts, or sources of extracts, of the genus Actinomyces;
• and compounds of Formula (I):
• wherein—
• the dotted lines represent simple or double bound;
• preferably one of the dotted line is a double bound;
• R1 represent an H, a carbonated chain, linear, cyclic, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• R2 represent a carbonated chain, linear, cyclic ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• preferably a methyl (—CH3) or methylene (═CH2) moiety;
• a represent a carbonated chain, linear, ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• preferably from 1 to 10 carbon atoms;
• more preferably 6 carbon atoms;
• preferably an aromatic moiety, preferably a phenyl moiety;
• preferably 2-methyl-prop-1,3-diene;
• ii) one or more demulcents or soothing agents;
• and
• iii) optionally, an ophthalmologically acceptable carrier.

A method for promoting healing or increasing the rate of healing of wounds in and/or on the eye of a patient by administering compositions:

• i) a safe and effective amount of a compound and/or extract having retinol-like properties and/or benefits for use in treating dry eye selected from one or more of botanical extracts, or sources of extracts, from plants of the genus Acronychia, Licaria, Calendula and or Trigonella;
• bacterial extracts, or sources of extracts, of the genus Actinomyces;
• and compounds of Formula (I):
• wherein—
• the dotted lines represent simple or double bound;
• preferably one of the dotted line is a double bound;
• R1 represent an H, a carbonated chain, linear, cyclic, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• R2 represent a carbonated chain, linear, cyclic ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• preferably a methyl (—CH3) or methylene (═CH2) moiety;
• a represent a carbonated chain, linear, ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
• preferably from 1 to 10 carbon atoms;
• more preferably 6 carbon atoms;
• preferably an aromatic moiety, preferably a phenyl moiety;
• preferably 2-methyl-prop-1,3-diene.
• ii) optionally, an ophthalmologically acceptable carrier.