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AssigneeSpring Discovery, Inc.
InventorsRachel JACOBSON, Wendy COUSIN, An NGUYEN, Tempest PLOTT, William VAN TRUMP, Dat NGUYEN, Daniel CHEN, Jarred HEINRICH, Ben KOMALO, Lauren NICOLAISEN, Christian ELABD
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Disclosed herein are compositions and methods for increasing lifespan, for preventing or treating a disease including an aging-related disorder, for reducing a symptom of aging, and/or boosting an immune system in a mammal. Also disclosed herein are compositions and methods for improving effectiveness of a vaccine in a mammal. The compositions comprise, at least, a therapeutically effective amount of disulfiram and one or more additional ingredients.
-20. (canceled)
A method for inhibiting and/or reducing pyroptotic cell death in a cell, the method comprising contacting the cell with an active agent that is disulfiram and a potentiating ingredient that is cinnamaldehyde, thereby inhibiting and/or reducing pyroptotic cell death.
A method for boosting activity of an immune cell, the method comprising contacting the immune cell with an active agent that is disulfiram and a potentiating ingredient that is cinnamaldehyde, thereby boosting activity of the immune cell.
A composition comprising an active agent that is disulfiram and a potentiating ingredient that is cinnamaldehyde, wherein the amount of disulfiram is from about 5 mg to about 500 mg and the amount of cinnamaldehyde is from about 0.01% to about 45% of the of the disulfiram.
Dependencies are inferred from the claim text.