Transdermal patch of a portable ultrasound-generating system for improved delivery of therapeutic agents and associated methods of treatment

A method for transdermally administering a pharmaceutical composition to a subject, comprising:

• applying to a skin surface of the subject a transdermal patch, the transdermal patch comprising:
• an impermeable layer forming an upper surface of the transdermal patch;
• an adhesive layer forming at least a portion of a lower surface of the transdermal patch;
• a removable protective layer disposed on an adhesive surface of the adhesive layer;
• a first pharmaceutical composition comprising:
• a cannabis drug in an amount therapeutically effective for treating or alleviating acute or chronic pain associated with a disease or condition of the subject, the cannabis drug comprising at least one cannabinoid selected from the group consisting of tetrahydrocannabinol (THC), cannabinol (CB), cannabidiol (CBD), cannabichromene (CBC) and combinations thereof,
• a pharmaceutically acceptable carrier;
• and optionally
• one or more additional drug(s) effective for treatment of the disease or condition of the subject;
• and
• an actuator with an integrated piezo transducer located on a lower surface of the transdermal patch such that a metal surface of the transducer faces a direction of adhesion of the transdermal patch, the integrated piezo transducer having a low profile height of 6 mm or less, wherein the actuator is electronically connected to a processor of a portable energy generating module;
• activating the portable energy generating module, wherein the activated portable energy generating module generates a driving signal causing a vibration mode of the actuator to communicate ultrasound energy to the integrated piezo transducer which transforms and emits the ultrasound energy as surface acoustic waves (SAW);
• and
• applying the SAW emitted from the integrated piezo transducer to the transdermal patch and surrounding areas of the skin for a preset time and in a controlled manner, wherein the emitted SAW is of low power and low frequency in a range of 20-120 KHz,
• wherein the application of the SAW to the transdermal patch results in optimally enhanced delivery and administration of the cannabis drug to the subject as compared to transdermal administration of the cannabis drug without the application of SAW.

A method for treating or alleviating symptoms of a disease or condition of a subject, comprising:

• applying to a skin surface of the subject a transdermal patch, the transdermal patch comprising:
• an impermeable layer forming an upper surface of a transdermal patch;
• an adhesive layer forming at least a portion of a lower surface of the transdermal patch;
• a removable protective layer disposed on an adhesive surface of the adhesive layer;
• a first pharmaceutical composition comprising:
• a cannabis drug in an amount therapeutically effective for treating or alleviating acute or chronic pain associated with a disease or condition of the subject, the cannabis drug comprising at least one cannabinoid selected from the group consisting of tetrahydrocannabinol (THC), cannabinol (CB), cannabidiol (CBD), cannabichromene (CBC) and combinations thereof, and
• a pharmaceutically acceptable carrier;
• and
• an actuator in electrical communication with a processor of a portable energy generating module, the actuator comprising a transducer selected from the group consisting of a piezoelectric transducer, electromagnetic acoustic transducer, and laser pulse transducer, wherein the transducer is located on a lower surface of the transdermal patch so as to face a direction of adhesion of the transdermal patch;
• activating the portable energy generating module, wherein the activated portable energy generating module sends an electrical signal from the processor thereof to the actuator of the transdermal patch, resulting in the actuator generating high frequency mechanical vibrations that create surface acoustic waves (SAW) in a nanometer range through the transdermal patch and on the surface of the skin surrounding the transdermal patch;
• and
• applying the SAW generated by the actuator when the portable energy generating module is in the active state in a targeted manner for a preset time to effectuate controlled delivery of the pharmaceutical composition from the transdermal patch to the subject, wherein the delivery of the pharmaceutical composition through application of the SAW improves absorption of the pharmaceutical composition for treating or alleviating symptoms of the disease or condition of the subject.