Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
AssigneeEupraxia Pharmaceuticals USA LLC
InventorsJames A. Helliwell, Amanda M. Malone, Thomas J. Smith, Marc M. Baum
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Abstract
Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.
Claims15
A unit dosage form comprising:
- a plurality of microparticles, the microparticle including:
- (1) a crystalline drug core of more than 70% by weight of the microparticle;
- and
- (2) a polymeric shell encapsulating the crystalline drug core,
- wherein the crystalline drug core includes one or more crystals of a corticosteroid selected from fluticasone, fluticasone furoate, and fluticasone propionate, and the polymeric shell is in contact but immiscible with the crystalline drug core;
- and
- wherein the unit dosage form releases the corticosteroid over a period of 2-12 months while maintaining a minimum therapeutically effective concentration of the corticosteroid within a body compartment.
An extended release formulation comprising a plurality of microparticles having core/shell morphology, wherein the microparticle includes (1) a crystalline drug core of more than 70% by weight of the microparticle, wherein the crystalline drug core includes one or more crystals of a corticosteroid, a salt or ester thereof;
- and (2) a polymeric shell encapsulating the crystalline drug core, whereby the polymeric shell is in contact but immiscible with the crystalline drug core.
Dependencies are inferred from the claim text.