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US 2022/0087941 A1Published application
Oral delivery systems based on in situ forming protein/polysaccharide coacervates
Assignee9286-3620 Quebec Inc.
InventorRomain Caillard
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Assignee9286-3620 Quebec Inc.
InventorRomain Caillard
Estimating the term…
An oral delivery system based on in situ forming protein/polysaccharide coacervates is described herein. The system comprises an active ingredient dispersed in a dry, homogenous powder mixture of a protein powder and a polysaccharide powder, which is able to form a protein/polysaccharides complex coacervate in situ upon immersion in gastric fluid, thereby conferring gastric protection and/or modified-release to the active ingredient. Varying the ratio of protein powder to polysaccharide powder in the oral delivery system varies the level of gastric protection and/or rate of release to the active ingredient. The ability of the system described herein to be based on natural and/or naturally-derived biopolymers provides commercial advantages in terms of regulatory approval and/or growing consumer demand for such products.
An oral delivery system comprising or consisting essentially of a dry homogenous mixture comprising a protein powder and a polysaccharide powder mixture, and an active ingredient dispersed therein, the protein and polysaccharide powder mixture forming a protein/polysaccharide complex coacervate in situ upon immersion of the oral delivery system in a gastric fluid, thereby conferring gastric protection and/or modified release to the active ingredient, wherein varying the ratio of protein powder to polysaccharide powder in the oral delivery system varies the level of gastric protection and/or rate of release of the active ingredient, and wherein the polysaccharide powder has, or is conditioned to have, one or more of the following powder flow characteristics:
The oral delivery system of claim 12, wherein the polysaccharide powder has, or is conditioned to have, all the powder flow characteristics as defined in (a), (b), (c) and (d).
A process for preparing a solid oral dosage form, the process comprising dispersing an active ingredient in a dry homogenous mixture comprising a protein powder and a polysaccharide powder, and formulating the resulting mixture into a solid oral dosage form, the polysaccharide powder having powder flow characteristics enabling interaction with the protein powder such that immersion of the solid oral dosage form in a gastric fluid results in formation of a protein/polysaccharide complex coacervate in situ, thereby conferring gastric protection and/or modified-release to the active ingredient, and wherein the polysaccharide powder has, or is conditioned to have, one or more of the following powder flow characteristics:
(canceled)
Dependencies are inferred from the claim text.