Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine
AssigneeOcular Therapeutix, Inc.
InventorsCharles D. Blizzard, Rami El-Hayek, Michael Goldstein, Peter Jarrett, Andrew Vanslette
Life of this patent
Estimating the term…
Abstract
Provided herein are sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.
Claims30
A method of treating dry eye disease in a human subject in need thereof, the method comprising inserting into the canaliculus of the human subject a sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, wherein the cyclosporine is in the form of particles and wherein the cyclosporine particles are dispersed within the hydrogel.
A method of treating dry eye disease in a human subject in need thereof, the method comprising inserting into the canaliculus of the human subject a sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, wherein the insert in a dried state contains from about 40% to about 80% by weight of the cyclosporine based on the total weight of the insert.
A method of treating dry eye disease in a human subject in need thereof, the method comprising the steps of:
- (a) inserting a first biodegradable insert into a first canaliculus of a first eye of the subject, wherein the insert comprises:
- (1) a hydrogel;
- (2) from about 100 μg to about 800 μg cyclosporine dispersed in the hydrogel;
- (3) wherein the cyclosporine releases from the insert over a period of at least about 2-months from the date of inserting the first insert in the subject, at an average rate of about 0.1 μg/day to about 10 μg/day;
- and
- (b) after at least about 2-months from the date of inserting the first insert, inserting a second insert into the first canaliculus of the first eye in the subject, wherein the second insert is substantially similar to the first insert.
Dependencies are inferred from the claim text.