Optical systems and methods for intraoperative detection of csf leaks
AssigneesThe Board of Trustees of the Leland Stanford Junior University, Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum FüR Gesundheit Und Umwelt (GmbH)
InventorsTulio A. Valdez, Mahbuba Tusty, David Huland, Oliver Bruns
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Abstract
A multi-wavelength surgical system is provided using an endoscope sensitive in the short-wave infrared region which allows exploration of different areas of the skull base for CSF leaks. The device includes an LED box with multiple wavelengths including allowing excitation of ICG with 785-808 nm, enhancing the water absorption from 1200-1550 nm and above 1800 nm and incorporating white light to allow for surgical navigation. Because CSF is 99% water having a large absorption in the SWIR band around 1200-1550 nm and above 1800 nm, the system and method should be an effective means of diagnosis without the need for intrathecal fluorescein.
Claims22
An apparatus for detecting leakage of cerebrospinal fluid in a subject's body, comprising:
- an imaging device comprising a proximal end, a distal end sized for introduction into the body, and an imaging element carried by the distal end;
- a light source coupled to the imaging device to simultaneously deliver near infrared (IR) light to excite fluorescent dye administered to the body to cause the dye to fluoresce and deliver short wavelength infrared (SWIR) light;
- and
- a camera for acquiring images via the imaging element within the SWIR band to facilitate identifying a leak of cerebrospinal fluid.
A system for detecting leakage of cerebrospinal fluid in a subject's body, comprising:
- an imaging device comprising a proximal end, a distal end sized for introduction into the body, and an imaging element carried by the distal end;
- a light source coupled to the imaging device to simultaneously deliver near infrared (IR) light to excite fluorescent dye administered to the body to cause the dye to fluoresce and deliver short wavelength infrared (SWIR) light;
- a camera for acquiring images via the imaging element within the SWIR band to facilitate identifying a leak of cerebrospinal fluid;
- and
- a source of fluorescent dye for administration to the subject.
20-26. (canceled)
A method for detecting leakage of cerebrospinal fluid in a subject's body, comprising:
- administering fluorescent dye to the body;
- introducing an imaging device into a target location within the body;
- delivering near infrared light via the imaging device to excite the fluorescent dye to cause the dye to fluoresce;
- and
- acquiring images via the imaging device at a frequency between about 1200-2500 nm to identify a leak of cerebrospinal fluid within the target location.
28-47. (canceled)
Dependencies are inferred from the claim text.