Systems, devices, and methods related to the individualized calibration and/or manufacturing of medical devices

A continuous glucose monitoring system, comprising:

• an in vivo sensor configured to generate a signal associated with a glucose level of a user, the sensor including
• a first portion configured to be positioned beneath a skin surface of the user and including a working electrode and a counter electrode,
• a second portion configured to remain outside the user and including a first contact electrically coupled to the working electrode and a second contact electrically coupled to the counter electrode, and
• at least one interferent-eliminating membrane layer;
• and
• a sensor control unit, wherein the first contact and the second contact of the in vivo sensor are each electrically coupled to the sensor control unit, and wherein the sensor control unit is configured to evaluate the generated signal from the in vivo sensor using calibration information, wherein the calibration information is based at least in part on:
• a first device-dependent nonlinear function including a first manufacturing parameter;
• and
• a second device-dependent nonlinear function including a second manufacturing parameter.